Spravato increases glutamate, the most abundant neurotransmitter in the brain. Glutamate is a powerful excitatory neurotransmitter that regulates learning and memory. As glutamate levels increase, the neurotransmitter starts to “excite” cells in the brain. Glutamate also encourages the brain to learn, memorize, and become accustomed to this excited state of mind, helping to combat the symptoms of depression.